The Anti-Human Hace 1, Biotin (clone: 8D3) (Mouse IgG,k) Antibody from MyBioSource.com is a Mouse Monoclonal antibody. This antibody recognizes Human antigen. The Anti-Human Hace 1, Biotin (clone: 8D3) (Mouse IgG,k) Antibody has been validated for the following applications: ELISA, Flow Cytometry, Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot.
Description
Anti-Human HACE 1 monoclonal antibody binds HACE 1 (HECT domain and ankyrin repeat containing), an E3 ubiquitin protein ligase 1 that has ubiquitin ligase activity. HACE 1 was found to be a tumor suppressor which is down-regulated in human Wilm's tumor. HACE1 is frequently downregulated in human tumors and maps to a region of chromosome 6q21 implicated in multiple human cancers. Genetic inactivation of HACE1 results in the development of spontaneous, late-onset cancer. A second hit from either environmental triggers or genetic heterozygosity of another tumor suppressor, p53, markedly increases tumor incidence in a HACE 1-deficient background. Re-expression of HACE1 in human tumor cells directly abrogates in vitro and in vivo tumor growth, whereas downregulation of HACE1 via siRNA allows non-tumorigenic human cells to form tumors in vivo. Mechanistically, the tumor-suppressor function of HACE1 is dependent on its E3 ligase activity. HACE1 controls adhesion-dependent growth and cell cycle progression during cell stress by influencing the degradation of cyclin D1